A mom and "wholistic" chiropractor's musings and roadmap with Down syndrome

Posts tagged ‘nutrition’

TNI Dosing Charts


Nutrivene Daily Dosed by weight

·         daily dose is divided into two portions (am and pm is best) and given with meals

Daily Enzyme Dosed by weight

·         daily dose divided into 2-3 portions, and given with meals

NightTime Formula Dosed by weight, given at bedtime
PolyPhenol Complex

(1 product containing Resveratrol, EGCG, PQQ, Co Q-10, Vitamin C and Glutathione)

Dose off of resveratrol content for weight.  Each dose is given

·         Twice a day (ideal)

·         If once a day only- give at bedtime

·         Needs to be separate from Nutrivene daily by 4 hours

Curcumin Dosed by weight

·         10-30 mg/kg

·          best combined with PolyPhenol Complex

EFAs Dosed by weight- given am and pm
Glutathione Use for additional liver and detoxification support

·         4 mg/kg at bedtime general dose

·         Up to 8 mg/kg for vaccine, surgery, and drug detox

·         A glutathione rescue dose (4 mg/kg) needs to be given within 2 hours of every dose of acetomenophen (Tylenol)



<20 lbs (<9 kgs) ½ tsp or 2 capsules
21-40 lbs (10-18 kgs) ¾ tsp or 4 capsules (3/4tsp divided by 2 is 3/8tsp)
41-60 lbs (19-27 kgs) 1 tsp or 6 capsules
61-80 lbs (28-36 kgs) 1 ½ tsp or 9 capsules
Over 80 lbs (>37 kgs) 2 tsps or 12 capsules


WEIGHT TOTAL Enzyme dose (divided into 2-3 portions)
Infant to 15 lbs ¾ capsule
15-25 lbs 1 capsule
25-35 lbs 1 ½ capsules
35-50 lbs 2 capsules
50-70 lbs 2 ¼ capsules
70-100 lbs 3 capsules
Over 100 lbs (may want to switch to adult product) 3-4 capsules


WEIGHT TOTAL NightTime dose
Infant to 15 lbs ¼ capsule
15-25 lbs 1/2 capsule
25-35 lbs 1 capsule
35-50 lbs 1 1/2 capsules
50-70 lbs 2 capsules
70-100 lbs 3 capsules
Over 100 lbs 3 capsules


Nutrient in POLYPHENOL


Per 4 capsules

in mg

Per 3 capsules in mg Per 2 capsules in mg Per 1 capsule in mg Per 3/4 capsule in mg Per 1/2 capsule in mg Per 1/3 capsule in mg Per 1/4 capsule in mg
Vitamin C 100 75 50 25 18.75 12.5 8.33 6.25
CoQ10 60 45 30 15 11.25 7.5 5 3.75
Glutathione 40 30 20 10 7.5 5 3.33 2.5
EGCG 270 202.5 135 67.5 50.64 33.75 22.5 16.88
PQQ 20 15 10 5 3.75 2.5 1.66 1.25
Resveratrol 275 206.25 137.5 68.75 51.57 34.38 22.9 17.10

*another dosing option is that the polyphenol 1 capsule is the dose for 38 pounds/17kg at 4 mg/kg resveratrol

Individual Polyphenol Components (if not doing NuTriVene PolyPhenol Complex) Dosed by weight
Resveratrol Start at .5-1 mg/kg, and gradually workup to 4-5 mg/kg.  Give each dose 2 times a day 8 hours apart.
EGCG Start at .5-1 mg/kg, and gradually workup to 4-5 mg/kg.  Give each dose 2 times a day 8 hours apart. Must be 4 hours away from Nutrivene Daily.
PQQ Infants 3 mg, toddlers 5 mg, children 10 mg, adults 20 mg. Give with EGCG, once a day.

*In Infants, it is often easier to give these separately, to control the dose and it is worked up, and until the child reaches a weight where they can easily switch to the polyphenol capsules.


NuTriVene Products

Nutrivene products- the foundation of Targeted Nutritional Intervention (TNI)


NuTriVene-D is the main supplement in the treatment of Down syndrome, and the one to start with. It was developed by a team of researchers and scientists.  It’s purpose is to provide nutritional agents, such as vitamins, minerals and amino acids, in specific forms and amounts to help offset or manage several of the genes over-expressing in Trisomy 21/ Down syndrome.

“The Daytime Formula targets all the aberrant nutritional needs of kids with DS. It corrects the damage to the folate/methyl cycle caused by the over expression of the CBS gene. It provides all of the missing precursors for normal thyroid function. It provides nutrients found in low quantities necessary for immune response. It targets oxidative stress caused by the over expression of SOD1. There are there antioxidant enzymes in the oxidative triad that must be in levels sufficient to work in synergy. When they do not work, the cells fill up with hydrogen peroxide. Hydrogen peroxide then becomes the most deadly free radical known to man, the hydroxyl free radical. So, in addition to providing other antioxidants, Nutrivene Daytime Formula upregulates the two antioxidant enzymes that are NOT located on chromosome 21, Catalase and Glutathione Peroxidase and therefore far too low for the triad to function. But by up regulating them as much as possible, this triad functions much better. The Daytime Formula normalizes the child’s biochemistry as much as possible in the exact levels required.”

– Dixie Lawrence, DS Biochemist and Researcher

To read the list of article about Nutrivene-D please go here http://www.nutrivene.com/educational_information.php



If you have an infant, start with the NuTriVene Daily Formula.  It comes with dosage information, as dosage is based on the weight of your child.  I recommend starting at 1/4 of the dose for your child, and gradually work up to the full dose.  The full dose split into 2 doses a day ensures your child has better blood saturation of the product.

There are 2 other parts of NuTriVene,  the NuTriVene Daily Enzymes and the NuTriVene NightTime Formula.


The NuTriVene enzymes are digestive enzymes.  These help to break down food so that it is more easily digested, and nutrients are better absorbed and assimilated by the body.  For infants, do not start this product until solids are introduced….however infants on formula may benefit from this product.  Infants with acid reflux  may have a worsening of reflux with this product.  Dosage recommendations come with this product.

To use, you can open up the capsule and sprinkle into or onto food, until your child is old enough to swallow pills.  Our webstore also carries some other digestive enzyme options, including a chewable one!


NuTriVene NightTime formula helps provide nutrients to support growth hormone and serotonin production.

Growth hormone can be deficient in people with T21.  This product makes sure the nutrients are available for the pituitary gland to make growth hormone.  The nutrients also help the body make serotonin, a neurotransmitter that can help with sleep, which is often low in children with T21/Ds.  Tis will better aid children with Ds to get into REM sleep- which is crucial for growth and development.  Dosage recommendations come with the product.

Please note that while all people with Trisomy 21 have genes that are over-expressing, each person still has an individual and unique biochemistry, and may be best served by working with a practitioner who specializes in TNI, to customize a specific protocol.